An outbreak of gastroenteritis due to Salmonella Give, a very rarely identified serotype in human isolates in Greece, occurred in participants of a religious festival in a rural area of southern of Greece, Region A , in September 2022. The objectives of this study were to describe the outbreak in terms of epidemiology, identify the vehicle of transmission of the foodborne pathogen and recommend prevention measures. The outbreak was linked to the consumption of a local traditional recipe of roast pork meat served by a street food vendor. In 2018, the same food item, served in a restaurant in the same Region A, was implicated in another S. Give outbreak. Outbreak investigations revealed that outbreak-associated S. Give isolates, of food and human source belong to the same S. Give strain. Significant deficiencies regarding food safety practices were identified. Both salmonellosis outbreaks highlighted the need for stricter compliance to all food safety and hygiene requirements at all stages of the food production process, from farms to processing facilities and retailers and restaurateurs to the final consumer.